S-adenosylhomocysteine: a better marker of the development of Alzheimer's disease than homocysteine?
نویسندگان
چکیده
Po-Yuan Changa, Shao-Chun Lub and Chu-Huang Chenc,d,e,∗ Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan Department of Biochemistry and Molecular Biology, National Taiwan University College of Medicine, Taipei, Taiwan Vascular and Medicinal Research, Texas Heart Institute at St. Luke’s Episcopal Hospital, Houston, TX, USA Department of Medicine, Baylor College of Medicine, Houston, TX, USA Department of Medicine, China Medical University Hospital, Taichung, Taiwan
منابع مشابه
Serum Levels of Homocysteine, Vitamin B12, and Folic Acid in Patients with Alzheimer’s Disease
Background: Alzheimer's disease is the most common form of dementia in the elderly. Serum levels of homocysteine have been related to increased cortical and hippocampal atrophy. We aimed to determine the serum levels of homocysteine, folate, and vitamin B12 in patients with Alzheimer's disease. Methods: Blood levels of homocysteine and its biological determinants, folate, and vitamin B12 were m...
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متن کاملS-Adenosylhomocysteine: a better indicator of vascular disease than homocysteine?
It is widely accepted that elevated plasma total homocysteine is an independent risk factor for vascular disease. The relation is believed to be causal, but there is no generally accepted mechanism for the pathophysiology involved. The metabolic precursor of homocysteine in all tissues is S-adenosylhomocysteine (AdoHcy). AdoHcy is present in normal human plasma at concentrations approximately 1...
متن کاملProtein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation.
Alzheimer's disease (AD) neuropathology is characterized by the accumulation of phosphorylated tau and amyloid-beta peptides derived from the amyloid precursor protein (APP). Elevated blood levels of homocysteine are a significant risk factor for many age-related diseases, including AD. Impaired homocysteine metabolism favors the formation of S-adenosylhomocysteine, leading to inhibition of met...
متن کاملS-adenosylhomocysteine and the ratio of S-adenosylmethionine to S-adenosylhomocysteine are not related to folate, cobalamin and vitamin B6 concentrations.
BACKGROUND It is unclear whether homocysteine itself is causal in the pathogenesis of cardiovascular disease. Alternatively or additionally, the association between homocysteine and cardiovascular disease may be because of its metabolic precursor, S-adenosylhomocysteine, or of the ratio of S-adenosylmethionine to S-adenosylhomocysteine. Therefore, it is relevant to know how these moieties are i...
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ورودعنوان ژورنال:
- Journal of Alzheimer's disease : JAD
دوره 21 1 شماره
صفحات -
تاریخ انتشار 2010